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J Cell Biol. 2009 Sep 7;186(5):637-44. doi: 10.1083/jcb.200906113. Epub 2009 Aug 31.

Paraspeckles: nuclear bodies built on long noncoding RNA.

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1
School of Biomedical, Biomolecular, and Chemical Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia.

Abstract

Paraspeckles are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei. These structures play a role in regulating the expression of certain genes in differentiated cells by nuclear retention of RNA. The core paraspeckle proteins (PSF/SFPQ, P54NRB/NONO, and PSPC1 [paraspeckle protein 1]) are members of the DBHS (Drosophila melanogaster behavior, human splicing) family. These proteins, together with the long nonprotein-coding RNA NEAT1 (MEN-epsilon/beta), associate to form paraspeckles and maintain their integrity. Given the large numbers of long noncoding transcripts currently being discovered through whole transcriptome analysis, paraspeckles may be a paradigm for a class of subnuclear bodies formed around long noncoding RNA.

PMID:
19720872
PMCID:
PMC2742191
DOI:
10.1083/jcb.200906113
[Indexed for MEDLINE]
Free PMC Article
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