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Mol Cell Endocrinol. 2010 Apr 29;318(1-2):24-33. doi: 10.1016/j.mce.2009.08.015. Epub 2009 Aug 29.

Fatty acid flux in adipocytes: the in's and out's of fat cell lipid trafficking.

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Department of Biochemistry, Molecular Biology and Biophysics, The University of Minnesota-Twin Cities, 321 Church St. SE, Minneapolis, MN 55455, USA.


The trafficking of fatty acids into and out of adipocytes is regulated by a complex series of proteins and enzymes and is under control by a variety of hormonal and metabolic factors. The biochemical basis of fatty acid influx, despite its widespread appreciation, remains enigmatic with regard to the biophysical and biochemical properties that facilitate long-chain fatty acid uptake. Fatty acid efflux is initiated by hormonally controlled lipolysis of the droplet stores and produces fatty acids that must transit from their site of production to the plasma membrane and subsequently out of the cells. This review will focus on the "in's and out's" of fatty acid trafficking and summarize the current concepts in the field.

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