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Adv Drug Deliv Rev. 2009 Nov 30;61(14):1332-1342. doi: 10.1016/j.addr.2009.06.009. Epub 2009 Aug 29.

Mitochondria in the elderly: Is acetylcarnitine a rejuvenator?

Author information

1
Center for Mitochondrial Diseases and Departments of Medicine and Pharmacology, Case Western Reserve University, Cleveland, Ohio.
#
Contributed equally

Abstract

Endogenous acetylcarnitine is an indicator of acetyl-CoA synthesized by multiple metabolic pathways involving carbohydrates, amino acids, fatty acids, sterols, and ketone bodies, and utilized mainly by the tricarboxylic acid cycle. Acetylcarnitine supplementation has beneficial effects in elderly animals and humans, including restoration of mitochondrial content and function. These effects appear to be dose-dependent and occur even after short-term therapy. In order to set the stage for understanding the mechanism of action of acetylcarnitine, we review the metabolism and role of this compound. We suggest that acetylation of mitochondrial proteins leads to a specific increase in mitochondrial gene expression and mitochondrial protein synthesis. In the aged rat heart, this effect is translated to increased cytochrome b content, restoration of complex III activity, and oxidative phosphorylation, resulting in amelioration of the age-related mitochondrial defect.

PMID:
19720100
PMCID:
PMC4120470
DOI:
10.1016/j.addr.2009.06.009
[Indexed for MEDLINE]
Free PMC Article

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