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Transfusion. 2010 Jan;50(1):139-44. doi: 10.1111/j.1537-2995.2009.02371.x. Epub 2009 Aug 31.

Appropriateness of fresh-frozen plasma usage in hospital settings: a meta-analysis of the impact of organizational interventions.

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1
Department of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy. gdamiani@rm.unicatt.it

Abstract

BACKGROUND:

Transfusions of fresh-frozen plasma (FFP) are a worldwide ever-growing practice. The most advanced health care organizations, to guarantee high-quality standards of interventions and safe procedures, should disseminate scientific evidence for promoting the appropriateness of transfusions and reducing avoidable risks.

STUDY DESIGN AND METHODS:

We carried out a systematic review of scientific literature searching for studies focused on the implementation of different strategy of organizational interventions aimed at improving clinicians' practice.

RESULTS:

Of 915 studies, 10 articles were included in our meta-analysis of risk of inappropriate transfusion after the implementation of an organizational intervention. The risk ratio of inappropriate transfusions before organizational interventions was 2.02 (95% confidence interval, 1.44-2.84) compared with after interventions.

CONCLUSION:

The organizational interventions showed a positive impact on the reduction of rates of inappropriate FFP transfusion episodes.

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