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J Med Chem. 2009 Aug 13;52(15):4582-5. doi: 10.1021/jm900378s.

Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity.

Author information

1
Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA.

Abstract

The synthesis and antibiofilm activities of sulfonamide, urea, and thiourea oroidin analogues are described. The most active derivative was able to selectively inhibit P. aeruginosa biofilm development and is also shown to be nontoxic upward of 1 mM to the development of C. elegans in comparison to other similar isosteric analogues and the natural product oroidin.

PMID:
19719234
PMCID:
PMC2739084
DOI:
10.1021/jm900378s
[Indexed for MEDLINE]
Free PMC Article

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