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Bone Marrow Transplant. 2010 Apr;45(4):723-9. doi: 10.1038/bmt.2009.223. Epub 2009 Aug 31.

IL-21 is critical for GVHD in a mouse model.

Author information

1
Division of Hematology, Department of Medicine, Jichi Medical University Tochigi, Tochigi, Japan.

Abstract

Immunological effects of IL-21 on T, B and natural killer (NK) cells have been reported, but the role of IL-21 in GVHD remains obscure. Here, we demonstrate that morbidity and mortality of GVHD was significantly reduced after BMT with splenocytes from IL-21R(-/-) mice compared with those from wild type mice. To further confirm our observation, we generated a decoy receptor for IL-21. GVHD was again less severe in mice receiving BM cells transduced with the IL-21 decoy receptor than control mice These results suggest that IL-21 critically regulates GVHD, and that blockade of the IL-21 signal may represent a novel strategy for the prophylaxis for GVHD.

PMID:
19718060
PMCID:
PMC3403836
DOI:
10.1038/bmt.2009.223
[Indexed for MEDLINE]
Free PMC Article

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