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Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Sep;108(3):e37-44. doi: 10.1016/j.tripleo.2009.05.037.

Preclinical animal model for de novo bone formation in human maxillary sinus.

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1
Department of Oral and Maxillofacial Surgery, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.

Abstract

OBJECTIVES:

Up to now the effect of bone-substitute materials on de novo bone formation has been tested in a variety of preclinical animal models. We hypothesized that there is no significant difference in bone regeneration after application of autogenous bone (AB) and bone substitutes in a porcine calvarial monocortical defect model and in human maxillary sinus.

STUDY DESIGN:

Twenty-four weeks after application of ss-tricalcium phosphate (betaTCP), hydroxyapatite (HA), and AB in each of 3 defects on the sculls of 6 adult pigs (N = 54) and the application in 44 sinus floor elevations (11x betaTCP, 6x HA and 24x AB) in 41 patients, bone regeneration rates where compared microradiographically. Wilcoxon rank-sum test was used for statistical analysis.

RESULTS:

Comparing the human with the animal specimens microradiographically, no significant difference of the mineralization rate could be found.

CONCLUSION:

The chosen porcine model is a valuable method for preclinical testing of bone-substitute materials in maxillofacial surgery.

PMID:
19716490
DOI:
10.1016/j.tripleo.2009.05.037
[Indexed for MEDLINE]
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