Format

Send to

Choose Destination
Trends Cell Biol. 2009 Sep;19(9):475-86. doi: 10.1016/j.tcb.2009.07.001. Epub 2009 Aug 26.

Multi-level molecular clutches in motile cell processes.

Author information

1
CNRS UMR 5091, Institut Magendie, Université Bordeaux 2, 33077 Bordeaux, France.

Abstract

To trigger cell motility, forces generated by the cytoskeleton must be transmitted physically to the external environment through transmembrane adhesion molecules. One model put forward twenty years ago to describe this process is the molecular clutch by which a modular interface of adaptor proteins mediates a dynamic mechanical connection between the actin flow and cell adhesion complexes. Recent optical imaging experiments have identified key clutch molecules linked to specific chemical and mechanical signal transduction pathways, particularly regarding integrins in migrating cells, IgCAMs in neuronal growth cones, and cadherins at intercellular junctions. We propose here the concept of a multi-level clutch as a useful analogy to grasp the complexity of the dynamic molecular interactions involved in a panel of motile behaviors and shapes.

PMID:
19716305
DOI:
10.1016/j.tcb.2009.07.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center