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Inflamm Res. 2010 Jan;59(1):63-70. doi: 10.1007/s00011-009-0070-2.

Surface markers of lymphocyte activation in pregnant asthmatics.

Author information

1
Department of Pulmonology, Semmelweis University, Budapest, Hungary. szatmari-bohacs@freemail.hu

Abstract

PROBLEM:

Pregnancy-associated immunologic alterations may improve the course of asthma. Severe maternal asthma with an exacerbation impairs fetal growth.

METHOD OF STUDY:

Lymphocyte activation was estimated by flow cytometry analysis of surface markers in non-pregnant healthy and mild or moderate persistent asthmatic women and healthy as well as mild or moderate persistent asthmatic, third trimester pregnant women.

RESULTS:

Compared with non-pregnant healthy subjects (n = 12) activated pools within CD4 and CD8 T cells were larger and the number of NK T cells were increased both in non-pregnant asthmatic (n = 12) and in healthy pregnant (n = 13) subjects (all p\0.05). No further lymphocyte activation was observed in pregnant asthmatics (n = 21) compared either with non-pregnant asthmatic, or pregnant healthy women. Average birth weight of newborns was lower (p\0.05) in the asthmatic than in the healthy pregnant group.

CONCLUSION:

Pregnancy is a state of wide-spread lymphocyte activation but it may blunt lymphocyte activation which characterizes bronchial asthma.

PMID:
19714295
PMCID:
PMC2803259
DOI:
10.1007/s00011-009-0070-2
[Indexed for MEDLINE]
Free PMC Article

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