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Am J Hypertens. 2009 Nov;22(11):1148-53. doi: 10.1038/ajh.2009.155. Epub 2009 Aug 27.

Serum estrogen metabolites and systolic blood pressure among middle-aged and older women and men.

Author information

1
Section of General Internal Medicine and the Department of Medicine, University of Chicago, IL, USA. cmasi@medicine.bsd.uchicago.edu

Abstract

BACKGROUND:

Hypertension is more common among men at younger ages and among women after age 60, suggesting a possible link between endogenous estrogens and systolic blood pressure (SBP). We tested whether serum 17beta-estradiol (E(2)) or any of its metabolites were associated with SBP among middle-aged and older adults.

METHODS:

Using a cross-sectional study design, we examined data from a population-based sample of 98 adults living in Cook County, Illinois. Age ranged between 55 and 69 years and body mass index (BMI) ranged between 19.8 and 50.6 kg/m(2). Serum was analyzed for 17beta-E(2) and 14 estrogen metabolites (EMs) using mass spectrometry. SBP was measured using a tonometric device that records a pulse wave at the radial artery. Demographic and health history information were obtained via questionnaires.

RESULTS:

Univariate analysis revealed an inverse relationship between SBP and both natural log (ln) 16alpha-hydroxyestrone (OHE(1)) (r = -0.360, P < 0.05) and ln 16-ketoestradiol (ketoE(2)) (r = -0.360, P < 0.05) among women but not men. No significant correlations were found between SBP and 17beta-E(2) in either sex. In multivariate analysis which adjusted for age, race, ethnicity, BMI, and use of cardiovascular medications, ln 16alpha-hydroxyestrone (16alpha-OHE(1)) (B = -5.3, s.e. = 2.1, P < 0.05) and ln 16-ketoE(2) (B = -4.7, s.e. = 1.9, P < 0.05) continued to be negatively associated with SBP among postmenopausal women.

CONCLUSIONS:

These data suggest that serum 16alpha-OHE(1) or 16-ketoE(2) may be important for vascular health among postmenopausal women but not among similarly aged men.

PMID:
19713943
PMCID:
PMC2766426
DOI:
10.1038/ajh.2009.155
[Indexed for MEDLINE]
Free PMC Article

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