Stem cells: The promises and perils of p53

Nature. 2009 Aug 27;460(7259):1085-6. doi: 10.1038/4601085a.

Abstract

Five studies show that disabling p53, an essential tumour-suppressor protein, improves the efficiency of stem-cell production. Are these results a ‘heads up’ that cancer cells and stem cells are disturbingly similar?

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Cell Division
  • Cellular Reprogramming*
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16 / deficiency
  • Cyclin-Dependent Kinase Inhibitor p16 / genetics
  • Cyclin-Dependent Kinase Inhibitor p16 / metabolism
  • Fibroblasts / cytology
  • Fibroblasts / metabolism
  • Humans
  • Mice
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neoplasms / therapy
  • Pluripotent Stem Cells / cytology*
  • Pluripotent Stem Cells / metabolism*
  • Tumor Suppressor Protein p53 / deficiency
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Cdkn2a protein, mouse
  • Cyclin-Dependent Kinase Inhibitor p16
  • Tumor Suppressor Protein p53