Abstract
Five studies show that disabling p53, an essential tumour-suppressor protein, improves the efficiency of stem-cell production. Are these results a ‘heads up’ that cancer cells and stem cells are disturbingly similar?
MeSH terms
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Animals
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Cell Division
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Cellular Reprogramming*
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Cellular Senescence
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Cyclin-Dependent Kinase Inhibitor p16 / deficiency
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Cyclin-Dependent Kinase Inhibitor p16 / genetics
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Cyclin-Dependent Kinase Inhibitor p16 / metabolism
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Fibroblasts / cytology
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Fibroblasts / metabolism
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Humans
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Mice
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Neoplasms / metabolism
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Neoplasms / pathology
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Neoplasms / therapy
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Pluripotent Stem Cells / cytology*
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Pluripotent Stem Cells / metabolism*
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Tumor Suppressor Protein p53 / deficiency
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Tumor Suppressor Protein p53 / genetics
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Tumor Suppressor Protein p53 / metabolism*
Substances
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Cdkn2a protein, mouse
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Cyclin-Dependent Kinase Inhibitor p16
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Tumor Suppressor Protein p53