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Cerebrovasc Dis. 2009;28(4):406-10. doi: 10.1159/000235628. Epub 2009 Aug 22.

Partial occlusion of the descending aorta increases cerebral blood flow in a nonstroke porcine model.

Author information

1
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.

Abstract

BACKGROUND:

We studied the effect of partial aortic occlusion on cerebral perfusion and cardiac performance using the intra-aortic NeuroFlo catheter.

METHODS:

Adult pigs were instrumented to determine cardiac parameters; unique isotope-labeled microspheres were used to determine cerebral blood flow (CBF) before, during and after sequential partial aortic occlusion.

RESULTS:

Six pigs were studied; there was no relevant change in cardiac output, and the desired pressure drop of 10-15 mm Hg across the balloons was achieved. CBF increased significantly with inflation of the suprarenal balloon and remained elevated 90 min after deflation.

CONCLUSIONS:

Partial aortic occlusion with the NeuroFlo catheter significantly increased cerebral perfusion without adversely affecting cardiac performance.

PMID:
19713700
DOI:
10.1159/000235628
[Indexed for MEDLINE]

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