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Trends Cell Biol. 2009 Sep;19(9):447-54. doi: 10.1016/j.tcb.2009.06.003. Epub 2009 Aug 25.

Microtubule-dependent cell morphogenesis in the fission yeast.

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Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, GĂ©nopode Building, 1015 Lausanne, Switzerland.


In many systems, microtubules contribute spatial information to cell morphogenesis, for instance in cell migration and division. In rod-shaped fission yeast cells, microtubules control cell morphogenesis by transporting polarity factors, namely the Tea1-Tea4 complex, to cell tips. This complex then recruits the DYRK kinase Pom1 to cell ends. Interestingly, recent work has shown that these proteins also provide long-range spatial cues to position the division site in the middle of the cell and temporal signals to coordinate cell length with the cell cycle. Here I review how these microtubule-associated proteins form polar morphogenesis centers that control and integrate both spatial and temporal aspects of cell morphogenesis.

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