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J Nat Prod. 2009 Aug;72(8):1379-84. doi: 10.1021/np800781t.

Matrix metalloproteinase-2 inhibitors from Clinopodium chinense var. parviflorum.

Author information

1
Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.

Abstract

From the aerial parts of Clinopodium chinense var. parviflorum, nine new phenylpropanoids, clinopodic acids A-I (2-10), were isolated together with a known phenylpropanoid, rosmarinic acid (1). The structures of these new compounds were elucidated on the basis of spectroscopic analysis. Clinopodic acid C (4) showed MMP-2 inhibitory activity (IC(50) 3.26 microM).

PMID:
19711986
DOI:
10.1021/np800781t
[Indexed for MEDLINE]

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