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Int J STD AIDS. 2009 Sep;20(9):634-7. doi: 10.1258/ijsa.2008.008413.

Herpes simplex virus type 2 and HIV infection among US military personnel: implications for health prevention programmes.

Author information

1
US Military HIV Research Program, Division of Retrovirology, Walter Reed Army Institute of Research (WRAIR), Suite 250, Rockville, MD 20850, USA. cbautista@hivresearch.org

Abstract

US military personnel are routinely screened for HIV infection. Herpes simplex virus type 2 (HSV-2) is a risk factor for HIV acquisition. To determine the association between HSV-2 and HIV, a matched case-control study was conducted among US Army and Air Force service members with incident HIV infections (cases) randomly matched with two HIV-uninfected service members (controls) between 2000 and 2004. HSV-2 prevalence was significantly higher among cases (30.3%, 138/456) than among controls (9.7%, 88/912, P < 0.001). HSV-2 was strongly associated with HIV in univariate (odds ratio [OR] = 4.2, 95% confidence interval [CI] = 3.1-5.8) and multiple analyses (adjusted [OR] = 3.9, 95% CI = 2.8-5.6). The population attributable risk percentage of HIV infection due to HSV-2 was 23%. Identifying HSV-2 infections may afford the opportunity to provide targeted behavioural interventions that could decrease the incidence of HIV infections in the US military population; further studies are needed.

PMID:
19710337
DOI:
10.1258/ijsa.2008.008413
[Indexed for MEDLINE]

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