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Eur J Cancer Care (Engl). 2010 Jul;19(4):554-7. doi: 10.1111/j.1365-2354.2007.00847.x. Epub 2009 Aug 26.

Early (mucosal) gastric cancer with synchronous osteosclerotic bone metastases: a case report.

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Department of Gastroenterology, 251 Hellenic Air Force Hospital, Athens, Greece.


Early gastric cancer (EGC) is defined as an adenocarcinoma confined to the gastric mucosa or submucosa, regardless of the presence of lymph node metastases. Early gastric cancer carries an excellent prognosis, with a 5-year survival rate at least 85% in most series. However, there are rare cases where distant metastases exist. Bone metastases are rare in gastric cancer; osteoblastic bone metastases are even rarer. We report a patient with EGC (mucosal) and synchronous osteosclerotic bone metastasis. To our knowledge, this is the first reported case of submucosal EGC with synchronous bone metastases. The patient was operated and he received adjuvant chemotherapy and radiotherapy. He died 18 months after gastric surgery from generalized disease.

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