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Dermatol Surg. 2009 Dec;35(12):1978-84. doi: 10.1111/j.1524-4725.2009.01312.x.

A five-patient satisfaction pilot study of calcium hydroxylapatite injection for treatment of aging hands.

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Division of Dermatologic and Cosmetic Surgery, Department of Dermatology, The Mount Sinai Medical Center, New York, New York 10029-6574, USA.



The process of skin aging is not limited to the face but involves every part of the body, including the hands. A common manifestation of aging of the hands is the loss of volume, which occurs as the skin loses its subcutaneous fat. Injectable dermal fillers have surfaced as a popular method to address such deficiencies.


To report the use of calcium hydroxylapatite (CaHA) to address lost volume.


Five female subjects with soft tissue deficiency of the dorsa of the hands were enrolled at Mount Sinai Medical Center. A solution of CaHA with 2% lidocaine in amounts of 0.3 to 1.0 mL was injected interdigitally at each of three to five insertion sites; the sites were massaged and molded up to three times to ensure an optimal cosmetic end point. Subjects were seen for a follow-up visit after 1, 4, 16, and 24 weeks.


With a single injection, all subjects reached their correction goals without requiring any touch-ups. At the 24-week visit, the subjects retained the filling effect, with no adverse events and high patient satisfaction.


CaHA, a new, easily injectable, safe dermal filler, has emerged as an excellent option for soft tissue augmentation in aging hands.

[Indexed for MEDLINE]

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