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Cell Mol Life Sci. 2010 Jan;67(1):63-71. doi: 10.1007/s00018-009-0132-1. Epub 2009 Aug 26.

The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells.

Author information

1
Department of Cell Biology, Faculty of Science, Charles University in Prague, Prague, Czech Republic.

Abstract

Tumor cells exhibit at least two distinct modes of migration when invading the 3D environment. A single tumor cell's invasive strategy follows either mesenchymal or amoeboid patterns. Certain cell types can use both modes of invasiveness and undergo transitions between them. This work outlines the signaling pathways involved in mesenchymal and amoeboid types of tumor cell motility and summarizes the molecular mechanisms that are involved in transitions between them. The focus is on the signaling of the Rho family of small GTPases that regulate the cytoskeleton-dependent processes taking place during the cell migration. The multiple interactions among the Rho family of proteins, their regulators and effectors are thought to be the key determinants of the particular type of invasiveness. Mesenchymal and amoeboid invasive strategies display different adhesive and proteolytical interactions with the surrounding matrix and the alterations influencing these interactions can also lead to the transitions.

PMID:
19707854
PMCID:
PMC2801846
DOI:
10.1007/s00018-009-0132-1
[Indexed for MEDLINE]
Free PMC Article

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