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Chromosoma. 2009 Dec;118(6):683-92. doi: 10.1007/s00412-009-0234-4. Epub 2009 Aug 26.

H2AX: functional roles and potential applications.

Author information

1
Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. dickeyj@mail.nih.gov

Abstract

Upon DNA double-strand break (DSB) induction in mammals, the histone H2A variant, H2AX, becomes rapidly phosphorylated at serine 139. This modified form, termed gamma-H2AX, is easily identified with antibodies and serves as a sensitive indicator of DNA DSB formation. This review focuses on the potential clinical applications of gamma-H2AX detection in cancer and in response to other cellular stresses. In addition, the role of H2AX in homeostasis and disease will be discussed. Recent work indicates that gamma-H2AX detection may become a powerful tool for monitoring genotoxic events associated with cancer development and tumor progression.

PMID:
19707781
PMCID:
PMC3094848
DOI:
10.1007/s00412-009-0234-4
[Indexed for MEDLINE]
Free PMC Article

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