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PLoS One. 2009 Aug 25;4(8):e6741. doi: 10.1371/journal.pone.0006741.

Caenorhabditis elegans BAH-1 is a DUF23 protein expressed in seam cells and required for microbial biofilm binding to the cuticle.

Author information

1
Department of Cell and Tissue Biology, Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, USA. drace_km@mercer.edu

Abstract

The cuticle of Caenorhabditis elegans, a complex, multi-layered extracellular matrix, is a major interface between the animal and its environment. Biofilms produced by the bacterial genus Yersinia attach to the cuticle of the worm, providing an assay for surface characteristics. A C. elegans gene required for biofilm attachment, bah-1, encodes a protein containing the domain of unknown function DUF23. The DUF23 domain is found in 61 predicted proteins in C. elegans, which can be divided into three distinct phylogenetic clades. bah-1 is expressed in seam cells, which are among the hypodermal cells that synthesize the cuticle, and is regulated by a TGF-beta signaling pathway.

PMID:
19707590
PMCID:
PMC2727005
DOI:
10.1371/journal.pone.0006741
[Indexed for MEDLINE]
Free PMC Article

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