Format

Send to

Choose Destination
Blood. 2009 Oct 22;114(17):3652-5. doi: 10.1182/blood-2009-07-231894. Epub 2009 Aug 25.

Stage-specific susceptibility of human erythroblasts to Plasmodium falciparum malaria infection.

Author information

1
Center for Rare and Neglected Diseases, University of Notre Dame, South Bend, IN 46556, USA. ptamez@nd.edu

Abstract

Malaria parasites are known to invade and develop in erythrocytes and reticulocytes, but little is known about their infection of nucleated erythroid precursors. We used an in vitro cell system that progressed through basophilic, polychromatic, orthochromatic, and reticulocyte stages to mature erythrocytes. We show that orthochromatic cells are the earliest stages that may be invaded by Plasmodium falciparum, the causative agent of fatal human malaria. Susceptibility to invasion is distinct from intracellular survival and occurs at a time of extensive erythroid remodeling. Together these data suggest that the potential for complexity of host interactions involved in infection may be vastly greater than hitherto realized.

PMID:
19706885
PMCID:
PMC2766680
DOI:
10.1182/blood-2009-07-231894
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center