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Clin Pharmacokinet. 2009;48(8):489-516. doi: 10.2165/11317240-000000000-00000.

Pharmacokinetic optimization of immunosuppressive therapy in thoracic transplantation: part II.

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INSERM Unit 850, CHU Limoges, University of Limoges, Limoges, France.


Part I of this article, which appeared in the previous issue of the Journal, reviewed calcineurin inhibitors--ciclosporin and tacrolimus. In part II, we review the pharmacokinetics and therapeutic drug monitoring of mycophenolate and mammalian target of rapamycin inhibitors--sirolimus and everolimus--in thoracic transplantation, and we provide an overall discussion and suggest various areas for future study.

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