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Int J Biochem Cell Biol. 2009 Oct;41(10):2025-35. doi: 10.1016/j.biocel.2009.02.018. Epub 2009 Mar 5.

The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics.

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1
Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.

Abstract

Mutations in parkin, PTEN-induced kinase 1 (PINK1) and DJ-1 can all cause autosomal recessive forms of Parkinson's disease. Recent data suggest that these recessive parkinsonism-associated genes converge within a single pathogenic pathway whose dysfunction leads to the loss of substantia nigra pars compacta neurons. The major common functional effects of all three genes relate to mitochondrial and oxidative damage, with a possible additional involvement of the ubiquitin proteasome system. This review highlights the role of the mitochondrial kinase, PINK1, in protection against mitochondrial dysfunction and how this might relate to loss of substantia nigra neurons in recessive parkinsonism.

PMID:
19703660
PMCID:
PMC2732569
DOI:
10.1016/j.biocel.2009.02.018
[Indexed for MEDLINE]
Free PMC Article
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