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Chem Biol Drug Des. 2009 Sep;74(3):309-16. doi: 10.1111/j.1747-0285.2009.00863.x.

Structure activity relationship of antiproliferative agents using multiple linear regression.

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1
Spelman College, Atlanta, GA 30314, USA. lwinfield@spelman.edu

Abstract

With cancer-related fatalities being the second leading cause of death in the USA, understanding the activity of effective chemotherapeutic agents is critical to addressing prostate and other cancers. Celecoxib, an FDA-approved drug for the treatment of colon tumors, has been used successfully as a lead compound in the development of antiproliferative agents. The ability of celecoxib to inhibit the development and progression of tumors has been connected to a number of mechanisms of actions that are both dependent on and independent of its cyclooxygenase-2 activity. A structure-based approach has been employed to develop a model that underscores the structural significance of celecoxib as an antiproliferative agent. By evaluating the structure activity of this library of molecules, we were able to create a QSAR model for predicting the antiproliferative activity of structurally similar molecules. The development of the model will be presented in this paper.

[Indexed for MEDLINE]

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