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Exp Brain Res. 2009 Dec;199(3-4):423-33. doi: 10.1007/s00221-009-1964-5.

Spatial distribution of long-term potentiation in the surround of visual cortex lesions in vitro.

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1
Department of Neurology, Yale School of Medicine, New Haven, CT 06520, USA.

Abstract

Focal visual cortex lesions lead to functional changes in the surrounding cortical network, possibly mediated through synaptic long-term potentiation (LTP). Although a post-lesional facilitation of LTP has been observed, nothing is known about the spatial profile of LTP in the normal and focally lesioned visual cortex of rats. We used a 64-multielectrode array to characterise the spread of LTP induced by theta-burst stimulation in layer IV. Measurements were made at comparable distances from the midline in the visual cortex of controls, sham-operated and lesioned animals. In control rats, LTP was elicited in projections to all visual cortex layers. However, we completely failed to observe LTP in sham-operated animals 1-4 days after surgery. At comparable survival times, no LTP could be elicited in the lesion-treated rats in direct vicinity of the border of the injury, while LTP was successfully induced at larger distances from the lesion. The maximal reach of this restored post-lesion LTP was spatially more limited than in controls and equal in all directions, accordingly absolute distance and not maximal length or density of connections seems to rule local lesion-induced functional remodelling.

PMID:
19701631
DOI:
10.1007/s00221-009-1964-5
[Indexed for MEDLINE]
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