Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Neurosci. 2009 Sep;12(9):1090-2. doi: 10.1038/nn.2385. Epub 2009 Aug 23.

Neurod1 is essential for the survival and maturation of adult-born neurons.

Author information

1
Department of Molecular Biology and Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Abstract

The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.

PMID:
19701197
PMCID:
PMC3365543
DOI:
10.1038/nn.2385
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center