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Nat Genet. 2009 Sep;41(9):965-7. doi: 10.1038/ng.436. Epub 2009 Aug 23.

Genomic privacy and limits of individual detection in a pool.

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1
Computer Science Division, University of California, Berkeley, Berkeley, California, USA.

Abstract

Recent studies have demonstrated that statistical methods can be used to detect the presence of a single individual within a study group based on summary data reported from genome-wide association studies (GWAS). We present an analytical and empirical study of the statistical power of such methods. We thereby aim to provide quantitative guidelines for researchers wishing to make a limited number of SNPs available publicly without compromising subjects' privacy.

PMID:
19701190
DOI:
10.1038/ng.436
[Indexed for MEDLINE]

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