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Mol Gen Genet. 1990 Jan;220(2):334-8.

The fimD gene required for cell surface localization of Escherichia coli type 1 fimbriae.

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Department of Microbiology, Technical University of Denmark, Lyngby.


The fimD gene of Escherichia coli K12 was shown to be necessary for surface localization of type 1 fimbriae, since deletion of the gene resulted in a virtually bald phenotype. The FimD protein was found to be located in the outer membrane. Expressed alone, this protein had a very deleterious effect on cell growth. The DNA sequence of the fimD gene was determined; the corresponding amino acid sequence of the FimD protein was compared with those of the PapC and FaeD proteins. A deletion derivative of FimD gave clues as to which parts of the protein were necessary for outer membrane integration.

[Indexed for MEDLINE]

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