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Radiother Oncol. 2009 Dec;93(3):516-23. doi: 10.1016/j.radonc.2009.07.015. Epub 2009 Aug 21.

Oral cavity squamous cell carcinoma in 260 patients aged 80years or more.

Author information

1
Department of Radiotherapy, Centre Antoine-Lacassagne, Nice, France. c.ortholan@wanadoo.fr

Abstract

PURPOSE:

We report the experience of two French cancer centers in the treatment of oral cavity squamous cell carcinoma (SCC) in patients aged 80 years.

MATERIALS AND METHODS:

Two hundred and sixty patients aged 80 years with a primary oral cavity SCC were included in this retrospective analysis.

RESULTS:

Sex ratio was near to 1. Tobacco or alcohol intoxication was the main risk factor for 66% of men and 16% of women and leukoplakia, lichen planus, or oral traumatism for 55% of women and 11% of men (p<0.0001). Two hundred patients received a loco-regional (LR) treatment with a curative intent (surgery and/or radiotherapy), 29 with a palliative intent and 31 did not receive a LR treatment. Curative treatments were initially planned to be adapted to age in 118 patients (59%). The median disease-specific survival (DSS) was 29 months. In multivariate analysis, the independent prognostic factors for DSS were stage (HR=0.42 [0.24-0.72]), age (HR=0.43 [0.24-0.75]) and performance status (HR=0.50 [0.27-0.95]). The median overall survival (OS) was 14 months. In multivariate analysis, the independent prognostic factors for OS were age (HR=0.52 [0.35-0.79]), stage (HR=0.56 [0.38-0.84]), tumor differentiation (HR=0.60 [0.33-0.93]) and performance status (HR=0.6 [0.37-0.97]). In patients treated with a curative intent, treatment adapted to age was not associated with a decreased overall survival or disease-specific survival as compared with the standard treatment. However, prophylactic lymph node treatment in stages I-II tumors decreased the rate of nodal recurrence from 38% to 6% (p=0.01).

CONCLUSION:

This study emphasizes the need for prospective evaluation of standard and adapted schedules in elderly patients with oral cavity cancer.

PMID:
19699545
DOI:
10.1016/j.radonc.2009.07.015
[Indexed for MEDLINE]

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