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Int Immunopharmacol. 2009 Nov;9(12):1460-3. doi: 10.1016/j.intimp.2009.08.004. Epub 2009 Aug 20.

Serum adipsin levels in patients with seasonal allergic rhinitis: preliminary data.

Author information

1
Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino-University of Genoa, Genoa, Italy. gio.cip@libero.it

Abstract

BACKGROUND:

Several studies have outlined a possible relationship between adipokines and respiratory allergic diseases. However, there are no data about a role for adipsin in allergic rhinitis.

OBJECTIVE:

The aim of the study was to evaluate the serum adipsin levels in patients with seasonal allergic rhinitis (SAR), subdivided into two sub-groups: treated or not treated with sublingual immunotherapy (SLIT), and in a group of healthy controls.

METHODS:

The study included 110 subjects; i) 24 SLIT-treated SAR patients, ii) 62 untreated SAR patients, and iii) 24 normal subjects. All subjects were consecutively evaluated. A skin prick test and blood sampling for assessing serum adipsin levels were performed in all subjects.

RESULTS:

Serum adipsin was increased in SAR patients, even though significant only in males. There was also a significant positive association between adipsin and adiponectin.

CONCLUSION:

This preliminary study reports that adipsin serum levels may be increased in some SAR patients, but further functional studies should be performed.

PMID:
19699327
DOI:
10.1016/j.intimp.2009.08.004
[Indexed for MEDLINE]

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