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Immunity. 2009 Aug 21;31(2):342-55. doi: 10.1016/j.immuni.2009.06.023.

Dynamics of T cell, antigen-presenting cell, and pathogen interactions during recall responses in the lymph node.

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1
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720, USA.

Abstract

Memory T cells circulate through lymph nodes where they are poised to respond rapidly upon re-exposure to a pathogen; however, the dynamics of memory T cell, antigen-presenting cell, and pathogen interactions during recall responses are largely unknown. We used a mouse model of infection with the intracellular protozoan parasite, Toxoplasma gondii, in conjunction with two-photon microscopy, to address this question. After challenge, memory T cells migrated more rapidly than naive T cells, relocalized toward the subcapsular sinus (SCS) near invaded macrophages, and engaged in prolonged interactions with infected cells. Parasite invasion of T cells occurred by direct transfer of the parasite from the target cell into the T cell and corresponded to an antigen-specific increase in the rate of T cell invasion. Our results provide insight into cellular interactions during recall responses and suggest a mechanism of pathogen subversion of the immune response.

PMID:
19699173
PMCID:
PMC3704215
DOI:
10.1016/j.immuni.2009.06.023
[Indexed for MEDLINE]
Free PMC Article

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