Facial reconstruction is a challenging yet rewarding endeavor. The interpolated forehead and melolabial flaps are well-established methods for facial restoration, especially for the repair of nasal defects following excision of cutaneous malignancies. Repair of facial defects using interpolation flaps requires an appreciation of variations in skin thickness, facial contours, and functional concerns at the donor and recipient sites. A detailed review of flap design, modifications, and implementation is provided for the forehead and melolabial flaps.