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Mol Cell Endocrinol. 2010 Mar 5;316(1):79-85. doi: 10.1016/j.mce.2009.08.009. Epub 2009 Aug 19.

Interactions of sex hormone-binding globulin with target cells.

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  • 1Department of Medicine, St. Luke's/Roosevelt Hospital Center, College of, Physicians and Surgeons, Columbia University, New York, NY 10019, USA.


Sex hormone-binding globulin (SHBG) was initially described as a plasma protein synthesized in, and secreted by, the liver. It was discovered by its ability to bind certain androgens and estrogens and, for many years, was believed to serve as a transporter/reservoir for the steroids which it bound. Subsequently, it became clear that the cell membranes of selected tissues contained a receptor for SHBG (R(SHBG)). This review deals with what is known of that receptor - its anatomy, physiology and biochemistry.

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