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Steroids. 2009 Nov-Dec;74(13-14):1040-4. doi: 10.1016/j.steroids.2009.08.003. Epub 2009 Aug 19.

New oxandrolone derivatives by biotransformation using Rhizopus stolonifer.

Author information

1
H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan. hej@cyber.net.pk

Abstract

Structural transformation of the steroidal lactone, oxandrolone (1), by suspended-cell cultures of the plant pathogen fungus Rhizopus stolonifer, resulted in the production of three new metabolites. These metabolites were identified as 11alpha-hydroxyoxandrolone (2), 6alpha-hydroxyoxandrolone (3) and 9alpha-hydroxyoxandrolone (4), by different spectroscopic methods and single-crystal X-ray diffraction analysis for metabolite 2. Compounds 1 and 3 showed a significant beta-glucuronidase inhibitory activity.

PMID:
19698730
DOI:
10.1016/j.steroids.2009.08.003
[Indexed for MEDLINE]

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