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BMC Bioinformatics. 2009 Aug 23;10:261. doi: 10.1186/1471-2105-10-261.

Computing power of quantitative trait locus association mapping for haploid loci.

Author information

  • 1Department of Genetics, Rutgers University, 145 Bevier Road, Piscataway, NJ 08854, USA. gordon@biology.rutgers.edu

Abstract

BACKGROUND:

Statistical power calculations are a critical part of any study design for gene mapping. Most calculations assume that the locus of interest is biallelic. However, there are common situations in human genetics such as X-linked loci in males where the locus is haploid. The purpose of this work is to mathematically derive the biometric model for haploid loci, and to compute power for QTL mapping when the loci are haploid.

RESULTS:

We have derived the biometric model for power calculations for haploid loci and have developed software to perform these calculations. We have verified our calculations with independent mathematical methods.

CONCLUSION:

Our results fill a need in power calculations for QTL mapping studies. Furthermore, failure to appropriately model haploid loci may cause underestimation of power.

PMID:
19698182
PMCID:
PMC2738682
DOI:
10.1186/1471-2105-10-261
[PubMed - indexed for MEDLINE]
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