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Dig Dis Sci. 2010 Apr;55(4):1085-9. doi: 10.1007/s10620-009-0890-5. Epub 2009 Aug 21.

Polycystic ovary syndrome is associated with an increased prevalence of irritable bowel syndrome.

Author information

1
Department of Obstetrics/Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Abstract

INTRODUCTION:

Polycystic ovary syndrome (PCOS) affects 5-10% of reproductive-aged women. Irritable bowel syndrome (IBS) is a chronic intestinal disorder that affects up to 20% of adults, more often women. We evaluate if there is a relationship between these common conditions.

METHODS:

Polycystic ovary syndrome and control subjects were prospectively recruited. A questionnaire was given to determine their gastrointestinal symptoms. Body mass index (BMI) and percent body fat were also calculated.

RESULTS:

About 65 female subjects completed the study. Among the 36 PCOS patients, 15 subjects (42%) had IBS, compared to 3 subjects (10%) among controls (p < 0.01). Control subjects were leaner (BMI: 27.5 +/- 1.1 vs. 31.4 +/- 1.2 kg/m(2), p < 0.05) than PCOS patients. Among women with PCOS, those with IBS had a higher BMI (32.9 +/- 2.0 kg/m(2)) compared to those with PCOS but no IBS (30.3 +/- 1.6 kg/m(2)) and controls (27.5 +/- 1.1 kg/m(2); p < 0.05). This difference was true even after correcting for BMI and age (p < 0.01).

CONCLUSIONS:

Women with PCOS have a higher prevalence of IBS compared to healthy controls. When IBS is present with PCOS, a higher BMI and percent body fat is seen compared to PCOS alone.

PMID:
19697132
DOI:
10.1007/s10620-009-0890-5
[Indexed for MEDLINE]

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