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Ultrason Sonochem. 2010 Jan;17(1):17-20. doi: 10.1016/j.ultsonch.2009.06.017. Epub 2009 Jul 2.

Ultrasound-radiated synthesis of PAMAM-Au nanocomposites and its application on glucose biosensor.

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Department of Chemistry, East China Normal University, 3663 Zhong Shan Road North, Shanghai 200062, China.


Hybrid nanocomposites of carboxyl-terminated generation 4 (G 4) poly(amidoamine) dendrimers (PAMAM) with gold nanoparticles (AuNPs) encapsulated inside them were synthesized under ultrasound irradiation. The obtained nanocomposites were used to fabricate highly sensitive amperometric glucose biosensor which exhibited a high and reproducible sensitivity of 2.9 mA/mM/cm(2), response time less than 5 s, linear dynamic range from 0.1 to 15.8 microM, correlation coefficient of R(2)=0.9988, and limit of detection (LOD), based on S/N ratio (S/N=3) of 0.05 microM. A value of 2.7 mM for the apparent Michaelis-Menten constant K(M)(app) was obtained. The high sensitivity, wider linear range, good reproducibility and stability make this biosensor a promising candidate for portable amperometric glucose biosensor.

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