Format

Send to

Choose Destination
Anal Chem. 2009 Oct 1;81(19):7892-9. doi: 10.1021/ac901366n.

H/D exchange and mass spectrometry in the studies of protein conformation and dynamics: is there a need for a top-down approach?

Author information

1
Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA. Kaltashov@chem.umass.edu

Abstract

Hydrogen/deuterium exchange (HDX) combined with mass spectrometry (MS) detection has matured in recent years to become a powerful tool in structural biology and biophysics. Several limitations of this technique can and will be addressed by tapping into the ever expanding arsenal of methods to manipulate ions in the gas phase offered by mass spectrometry.

PMID:
19694441
PMCID:
PMC2805115
DOI:
10.1021/ac901366n
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Chemical Society Icon for PubMed Central
Loading ...
Support Center