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Nat Rev Neurosci. 2009 Sep;10(9):627-34. doi: 10.1038/nrn2681.

WNTs tune up the neuromuscular junction.

Author information

1
Department of Neurobiology, Aaron Lazare Biomedical Research Building, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

Abstract

Although WNTs have been long thought of as regulators of cell fate, recent studies highlight their involvement in crucial aspects of synaptic development in the nervous system. Particularly compelling are recent studies of the neuromuscular junction in nematodes, insects, fish and mammals. These studies place WNTs as major determinants of synapse differentiation and neurotransmitter receptor clustering.

PMID:
19693027
PMCID:
PMC3499984
DOI:
10.1038/nrn2681
[Indexed for MEDLINE]
Free PMC Article
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