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Bioorg Med Chem Lett. 2009 Sep 15;19(18):5346-50. doi: 10.1016/j.bmcl.2009.07.133. Epub 2009 Aug 6.

Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT(2C) agonists.

Author information

1
Department of Medicinal Chemistry, Pfizer Global Research and Development, Sandwich Laboratories, Sandwich, Kent CT13 9NJ, UK. mark.d.andrews@pfizer.com

Abstract

This Letter reports the design and synthesis of several novel series of piperazinyl pyrimidinones as 5-HT(2C) agonists. Several of the compounds presented exhibit good in vitro potency and selectivity over the closely related 5-HT(2A) and 5-HT(2B) receptors. Compound 11 was active in in vivo models of stress urinary incontinence.

PMID:
19692241
DOI:
10.1016/j.bmcl.2009.07.133
[Indexed for MEDLINE]

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