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Folia Biol (Praha). 2009;55(4):126-31.

Total-tau and phospho-tau(181Thr) in cerebrospinal fluid of neurologically intact population increase with age.

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Department of Neurology, Medical University of Lublin, Lublin, Poland.


Tau protein is a microtubule-associated molecule playing a crucial role in maintenance of neuronal integrity and in many neurodegenerative processes; its pathology has become a hallmark feature at the tissue level. The aim of the study was to estimate total tau and phospho-tau (Thr181) concentrations in cerebrospinal fluid of healthy population. Cerebrospinal fluid samples were taken from 129 subjects (age 18-77 years) without known neurologic or psychiatric condition. Both total-tau and phospho-tau levels showed significant correlation with age, which was more pronounced in older population.

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