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Head Neck. 2010 Apr;32(4):499-503. doi: 10.1002/hed.21220.

Never-smokers, never-drinkers: unique clinical subgroup of young patients with head and neck squamous cell cancers.

Author information

1
Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. slharris@unch.unc.edu

Abstract

BACKGROUND:

Young patients represent an increasing subgroup with head and neck cancer.

METHODS:

Patients between 18 and 39 years of age with newly diagnosed and previously untreated squamous cell cancers were identified.

RESULTS:

Seventy-eight patients met the selection criteria: 28 patients were never-smokers/never-drinkers (NSNDs), and 50 patients reported tobacco or alcohol abuse (smokers and/or drinkers [SD]). NSND patients were diagnosed at a younger median age (31.5 years vs 35.5 years, p = .007), were more likely to be female (75% vs 30%, p < .001) and white (89% vs 60%, p = .006), and were more likely to have tumors of the oral tongue (57% vs 24%, p = .003) and T1 disease (47% vs 20%, p = .01). There was no difference in 10-year relapse-free survival, but a suggestion of improved 10-year overall survival for NSND patients (71% vs 46%, p = .10).

CONCLUSIONS:

Young patients with head and neck squamous cell carcinoma (HNSCC) appear to have unique clinical profiles based on history of alcohol and tobacco abuse.

PMID:
19691028
DOI:
10.1002/hed.21220
[Indexed for MEDLINE]

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