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Lancet. 1990 Mar 17;335(8690):622-4.

Oestrogen receptor B-region polymorphism and spontaneous abortion in women with breast cancer.

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Department of Radiotherapy, Mount Sinai School of Medicine, New York, NY 10029.


To examine whether a variant human oestrogen receptor gene, which differs from the wild-type gene in the B region, was associated with spontaneous abortion, obstetric histories of breast cancer patients with this variant were compared with those of breast cancer patients with the wild-type gene. In women with the B-variant, 50% of pregnancies ended in spontaneous abortion, compared with 10% for women homozygous for the wild-type gene. B-variant women also had a higher proportion of spontaneous abortions and a higher number of spontaneous abortions per woman than did those with the wild-type gene.

[Indexed for MEDLINE]

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