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Int J Stroke. 2009 Aug;4(4):274-84. doi: 10.1111/j.1747-4949.2009.00317.x.

Hyperthermia exacerbates ischaemic brain injury.

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The Central Illinois Neuroscience Foundation, Bloomington, IL, USA.


Hyperthermia frequently occurs in stroke patients. Hyperthermia negatively correlates with clinical outcome and adversely effects treatment regiments otherwise successful under normothermic conditions. Preclinical studies also demonstrate that hyperthermia converts salvageable penumbra to ischaemic infarct. The present article reviews the knowledge accumulated from both clinical and preclinical studies about hyperthermia and ischaemic brain injury, examines current treatment strategies and discusses future research directions.

[Indexed for MEDLINE]

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