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Virchows Arch. 2010 Feb;456(2):167-79. doi: 10.1007/s00428-009-0815-x. Epub 2009 Aug 18.

Well-differentiated and dedifferentiated liposarcomas.

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1
Department of Pathology and INSERM U916, Institut BergoniƩ, Bordeaux, France. coindre@bergonie.org

Abstract

Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14-15 amplification involving MDM2 gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS.

PMID:
19688222
DOI:
10.1007/s00428-009-0815-x
[Indexed for MEDLINE]
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