Nanodoublers as deep imaging markers for multi-photon microscopy

Opt Express. 2009 Aug 17;17(17):15342-9. doi: 10.1364/oe.17.015342.

Abstract

We demonstrate the possibility to excite second-harmonic (SH) active Fe(IO(3))(3) nanocrystals with two distinct laser sources at 800 and 1550 nm, and we show, by a complementary experimental and numerical study, how the wavelength flexibility inherent to non-phase-matched SH nanoparticles can be efficiently exploited to increase imaging penetration depth of markers embedded in biological samples.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Computer Simulation
  • Iron / chemistry
  • Lasers
  • Mice
  • Microscopy / methods
  • Microscopy, Fluorescence, Multiphoton / methods*
  • Monte Carlo Method
  • Nanoparticles / chemistry
  • Nanotechnology / methods*
  • Nephelometry and Turbidimetry / methods
  • Optics and Photonics
  • Photons
  • Polystyrenes / chemistry

Substances

  • Polystyrenes
  • Iron