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Opt Express. 2009 Aug 17;17(17):14780-90.

Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light.

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1
Laser Microbeam and Medical Program (LAMMP), Beckman Laser Institute, University of California - Irvine, 1002 Health Sciences Road, Irvine, CA 92617, USA.

Abstract

We present a wide-field method for obtaining three-dimensional images of turbid media. By projecting patterns of light of varying spatial frequencies on a sample, we reconstruct quantitative, depth resolved images of absorption contrast. Images are reconstructed using a fast analytic inversion formula and a novel correction to the diffusion approximation for increased accuracy near boundaries. The method provides more accurate quantification of optical absorption and higher resolution than standard diffuse reflectance measurements.

PMID:
19687956
PMCID:
PMC2850818
[Indexed for MEDLINE]
Free PMC Article
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