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Bone Marrow Transplant. 1990 Feb;5(2):105-9.

An in vitro predictive test for clinical graft-versus-host disease in allogeneic bone marrow transplant recipients.

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Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.


An in vitro skin explant model has been used in an attempt to predict the severity of graft-versus-host disease (GVHD) in HLA-identical donor-recipient pairs. The skin explant model involves the use of donor lymphocytes which have been sensitized against recipient lymphocytes in vitro and then co-cultured with the recipient's skin. Thirteen patients were studied in a prospective manner and results from the skin explant model compared with the clinical status of the patient post-transplant showed good correlation (p less than 0.001). Results from T cell-depletion studies indicated a role for both CD4 and CD8 positive cells in GVHD. In conclusion the results confirmed that the skin explant assay is a useful and predictive test of GVHD in humans.

[Indexed for MEDLINE]

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