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Psychosomatics. 2009 Jul-Aug;50(4):416-9. doi: 10.1176/appi.psy.50.4.416.

Fatalities associated with clozapine-related constipation and bowel obstruction: a literature review and two case reports.

Author information

1
correspondence and M.D., 4333 Chemin de la Cote Ste-Catherine, Montreal, Quebec H3T 1E4. katharine.hibbard@mail.mcgill.ca

Abstract

BACKGROUND:

Constipation is an exceedingly common side effect of treatment with clozapine. In rare cases, this side effect has resulted in fatal complications.

OBJECTIVE:

The authors review the literature on fatal complications of clozapine-related constipation and bowel obstruction.

METHOD:

The authors provide two new case reports of patients who died of similar causes.

RESULTS:

There were seven reports of deaths from clozapine-related bowel obstruction in the literature, with the most common mechanisms of death being severe impaction leading either to feculent vomiting or bowel necrosis.

DISCUSSION:

The discussion outlines potential mechanisms and management of clozapine-related constipation.

PMID:
19687183
DOI:
10.1176/appi.psy.50.4.416
[Indexed for MEDLINE]

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