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J Child Psychol Psychiatry. 2009 Dec;50(12):1495-503. doi: 10.1111/j.1469-7610.2009.02116.x. Epub 2009 Jul 21.

Increased waking salivary cortisol and depression risk in preschoolers: the role of maternal history of melancholic depression and early child temperament.

Author information

  • 1Department of Psychology, University of Maryland, College Park, 20742, USA. ldougherty@psyc.umd.edu

Abstract

BACKGROUND:

Elevated morning cortisol is a prospective predictor of major depression and may serve as a vulnerability marker. We examined the relation between morning cortisol and two prominent risk factors for depression in preschool-aged children: maternal depression and child temperament. We also explored whether maternal depression during the child's life, parental hostility and life stress explained these associations.

METHODS:

Ninety-four children provided a morning salivary cortisol sample, and 92 children provided an evening sample. Child temperament and parenting were assessed using observational measures, and maternal depression and life stress were assessed with clinical interviews.

RESULTS:

Maternal history of melancholic depression and child temperamental low positive emotionality were significantly associated with higher morning cortisol. These relations persisted after controlling for children's negative emotionality and concurrent depressive symptoms, parental hostility, and life stress.

CONCLUSIONS:

Our findings support the hypothesis that elevated morning cortisol may serve as an early-emerging vulnerability factor for depression, and highlight the importance of anhedonia in risk for depression.

PMID:
19686335
PMCID:
PMC2804780
DOI:
10.1111/j.1469-7610.2009.02116.x
[PubMed - indexed for MEDLINE]
Free PMC Article
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